ISESCO's Permanent headquarters has been built in an area of 11.253 m2, donated by late King Hassan II , in Hay Riyad, Madinate Al Irfane. Generous donations towards the construction of the new headquarters were made by :

• The Custodian of the Two Holy Mosques King Abdullah bin Abdulaziz Al-Saud,
• Late His Highness Sheikh Zayed bin Sultan Al Nahyan,
• Late His Highness Sheikh Jaber Al Ahmad As-Sabah,
• His Majesty Sultan Qabous bin Said,
• His Royal Highness Prince Talal bin Abdulaziz Al Saud,
• His Highness Sheikh Dr Sultan Bin Mohamed Al Qassimi.

and with the efforts, follow-up and supervision of:

His Excellency the Director General of ISESCO, Dr. Abdulaziz Othman Altwaijri.

The edifice consists of a couple of buildings separated by a vast hall:

• The first building is made up of one level designed for a conference hall, two assembly rooms and their annexes.
• The second building is made up of five levels designed for administrative and professional offices.
• The edifice has two main entrances. The first entrance overlooks the Avenue des F.A.R., and the second is located in front of the International Hall of Residence.

First Building: Conferences building It has a separate VIP entrance, and consists of: A reception hall. A VIP lounge. A spacious conference room. Two assembly rooms. 6 booths for simultaneous interpretation. A control room . An elevator. Second building: Administrative and professional offices The basement consists of the following: A parking for 70 vehicles. Archive premises. A printing office. Warehouses. The ground floor consists of the following: A reception hall decorated with a fountain at the entrance of the building. A prayer room, a library and a cafeteria. 13 administrative and professional bureaus, a technical office and a room of technical control.

The First floor

• It consists of seven (7) bureaus for specialized Directorates, (48) administrative and professional bureaus, (2) reception rooms.

The Second floor

• It consists of seven (7) bureaus for specialized Directorates, (26) administrative and professional bureaus, (2) reception rooms.

The Third floor

• It has the same specifications of the second floor. It contains the office of the Deputy Director General in addition to a number of Directorates and specialized services. 

The Fourth floor

• It consists of the office of the Director General in addition to a gathering hall, a reception lounge, (5) bureaus for specialized Directorates and (17) administrative and professional bureaus.
• The building contains (4) elevators and (4) staircases.
• The building is equipped with surveillance cameras and fire-extinguishing material.
• The headquarters is surrounded by gardens with passages. The entrance of the conferences' building is decorated with a traditional fountain.