2.1 Autosomal Dominant Inheritance

Human disorders inherited as autosomal dominants could be either homozygous or heterozygous. In case of the heterozygous, there will be a 50% chance that the child of an affected parent will be affected (Fig.1-a).

However, the clinical expression of disorder will be the same in both homozygous and heterozygous. Affected individuals for example are Huntington’s disease, myotic dystrophy and neurofibromatosis.