7.1.2.2 Life Cycle

The infection of the adenovirus is highly complex. It first binds to the cellular membrane receptors, then enter the cell by the process of endocytosis. Inside the cell, the virus is released from the endosome and the viral capsid disassembles during its movement towards the nuclear pore. The viral DNA enters the nucleus through the nuclear pore and remains in the nucleus as a separate episomal state. The DNA is then replicated by the help of the early proteins. The transcription then followed by the help of late genes to give rise to the capside protein.