7.1 Viral Vectors for Gene Therapy

The modification of viruses for the delivery of exogenous genes was first reported in 1968, using the tobacco mosaic virus. Then followed by using viruses, infecting mammalian cells and led to development of modified simian papiloma virus SV40. Recombinant DNA technology, now using vectors capable of transferring and expressing the genes in culture are in progress. The most commonly used viral vectors are Retrovirus, Adenovirus, Adeno associated virus and herpes viru